August 12, 2004
METABASIS ANNOUNCES SECOND QUARTER 2004 FINANCIAL RESULTS

August 3, 2004

METABASIS ANNOUNCES INITIATION OF A MULTI-CENTER PHASE 2 CLINICAL TRIAL OF REMOFOVIR FOR THE TREATMENT OF HEPATITIS B

July 27, 2004

METABASIS TO HOST CONFERENCE CALL AND LIVE WEBCAST TO DISCUSS SECOND QUARTER 2004 FINANCIAL RESULTS

July 26, 2004

METABASIS ANNOUNCES ISSUANCE OF A KEY PATENT COVERING ITS HEPDIRECT LIVER TARGETING PRODRUG TECHNOLOGY

July 13, 2004

METABASIS ANNOUNCES PUBLICATION OF A NEW MOLECULAR MODELING TECHNOLOGY FOR IMPROVING DRUG DISCOVERY AND OPTIMIZATION

June 25, 2004

METABASIS THERAPEUTICS HEPDIRECT™ LIVER TARGETING PRODRUG TECHNOLOGY DESCRIBED IN THE JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
NATURE Highlights HepDirect™ in News and Views

June 16, 2004

METABASIS THERAPEUTICS, INC. ANNOUNCES PRICING OF INITIAL PUBLIC OFFERING

April 29, 2004

METABASIS THERAPEUTICS, INC. ANNOUNCES APPOINTMENT OF DANIEL D. BURGESS, M.B.A. TO ITS BOARD OF DIRECTORS

April 16, 2004

METABASIS REPORTS THE EARNING OF A MILESTONE PAYMENT BASED ON CONTINUED DEVELOPMENT OF REMOFOVIR FOR THE TREATMENT OF HEPATITIS B

April 8, 2004

METABASIS THERAPEUTICS, INC. ANNOUNCES RECEIPT OF A MILESTONE PAYMENT AFTER COMPLETION OF A SUCCESSFUL PHASE IIA STUDY OF CS-917, A DRUG TO TREAT TYPE 2 DIABETES MELLITUS

February 3, 2004

METABASIS THERAPEUTICS, INC. FILES REGISTRATION STATEMENT FOR INITIAL PUBLIC OFFERING OF COMMON STOCK

January 13, 2004

METABASIS THERAPEUTICS AND MERCK ANNOUNCE A COLLABORATION TO DEVELOP NEW TREATMENTS FOR HEPATITIS C

October 28, 2003

METABASIS THERAPEUTICS, INC. COMPLETES $24.9 MILLION PRIVATE FINANCING

October 16, 2003
METABASIS THERAPEUTICS, INC. AWARDED A TWO YEAR, $2.4 MILLION PHASE II SBIR GRANT TO IDENTIFY HEPATITIS C DRUGS

October 7, 2003

METABASIS THERAPEUTICS, INC. ANNOUNCES THAT DR. SCOTT HECKER HAS JOINED AS EXECUTIVE DIRECTOR OF CHEMISTRY

September 26, 2003

METABASIS THERAPEUTICS, INC. ANNOUNCES THE COMPLETION OF A PHASE 2A STUDY OF CS-917, A DRUG TO TREAT TYPE 2 DIABETES MELLITUS

September 23, 2003

METABASIS THERAPEUTICS, INC. ANNOUNCES THE COMMENCEMENT OF CLINICAL TESTING OF MB7133 IN PATIENTS WITH PRIMARY LIVER CANCER

April 3, 2003

METABASIS THERAPEUTICS, INC. ANNOUNCES THE COMMENCEMENT OF CLINICAL TESTING OF HEPAVIR B IN PATIENTS WITH HEPATITIS B

January 3, 2003

METABASIS THERAPEUTICS, INC. TO PRESENT AT J.P. MORGAN H&Q ANNUAL HEALTHCARE CONFERENCE

October 31, 2002

RIBAPHARM SUBMITS INVESTIGATIONAL NEW DRUG APPLICATION FOR HEPAVIR B - A POTENTIAL NEW TREATMENT FOR THE MORE THAN 1.25 MILLION AMERICANS CHRONICALLY INFECTED WITH THE HEPATITIS B VIRUS

October 29, 2002

METABASIS THERAPEUTICS, INC. AND SANKYO CO., LTD. SIGN OPTION AGREEMENT FOR DISCOVERY AND DEVELOPMENT OF SECOND-GENERATION GLUCONEOGENESIS INHIBITOR FOR THE TREATMENT OF DIABETES

August 7, 2002
METABASIS THERAPEUTICS, INC. ANNOUNCES THAT DR. BILL FORBES HAS JOINED AS VICE PRESIDENT OF CLINICAL DEVELOPMENT AND REGULATORY AFFAIRS

May 22, 2002

METABASIS THERAPEUTICS, INC. ANNOUNCES THAT DR. ED BARACCHINI HAS JOINED AS VICE PRESIDENT OF BUSINESS DEVELOPMENT

January 8, 2002
METABASIS THERAPEUTICS, INC. IS ISSUED A US PATENT COVERING ITS HEPDIRECTTM TECHNOLOGY

December 11, 2001
METABASIS THERAPEUTICS, INC. ANNOUNCES THE FORMATION OF ITS SCIENTIFIC ADVISORY BOARD

November 1, 2001
METABASIS THERAPEUTICS, INC. AWARDED SBIR GRANT TO DISCOVER NOVEL AGENTS TO TREAT LIVER FIBROSIS/CIRRHOSIS

October 23, 2001
METABASIS THERAPEUTICS, INC. ANNOUNCES THE COMPLETION OF A PRIVATE PLACEMENT OF STOCK RAISING $19.2 MILLION

October 2, 2001
METABASIS THERAPEUTICS, INC. ANNOUNCES THE SIGNING OF A DEVELOPMENT AND LICENSE AGREEMENT FOR ITS HepDirect™ HEPATITIS B THERAPEUTIC WITH ICN PHARMACEUTICALS, INC.

August 30, 2001
METABASIS THERAPEUTICS, INC. AWARDED SBIR GRANT TO DISCOVER LIVER TARGETED HEPATITIS B PRODRUGS

August 1, 2001
METABASIS THERAPEUTICS, INC. ANNOUNCES THE INITIATION OF HUMAN CLINICAL TRIALS FOR ITS DRUG TO TREAT DIABETES MELLITUS

March 20, 2001
METABASIS THERAPEUTICS, INC. ANNOUNCES EXTENSION OF ITS COLLABORATION WITH SANKYO TO DEVELOP NEW DRUGS TO TREAT DIABETES MELLITUS

March 19, 2001
METABASIS THERAPEUTICS, INC. ANNOUNCES THAT DR. DAVID LINEMEYER HAS JOINED AS HEAD OF BIOLOGY RESEARCH

September 19, 2000
METABASIS THERAPEUTICS, INC. ANNOUNCES CHANGES TO ITS BOARD OF DIRECTORS

July 18, 2000
METABASIS THERAPEUTICS, INC. RAISES $13 MILLION TO FUND DEVELOPMENT OF ITS LIVER RELATED DISEASE PROGRAM

February 10, 2000
METABASIS THERAPEUTICS, INC. ANNOUNCES AN EXTENSION OF ITS COLLABORATION WITH SANKYO FOR DEVELOPMENT OF A NEW DRUG TO TREAT DIABETES